Imidazolyl derivatives of enalapril as potential angiotensin converting enzyme inhibitors
Cecchi, R.; Ciabatti, R.; Favara, D.; Barone, D.; Baldoli, E.
Il Farmaco; Edizione Scientifica 40(8): 541-554
1985
ISSN/ISBN: 0430-0920 PMID: 2995119 Document Number: 256414
The synthesis of a few derivatives of the angiotensin converting enzyme inhibitor enalapril is described. In these molecules the chelating carbethoxy group is substituted with an imidazolyl one. The compounds were tested both in vitro and in vivo in rats. None of them showed in vivo activity but only a marginal in vitro inhibitory activity.
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