Prolyl derivatives of enalapril as potential angiotensin converting enzyme inhibitors
Ciabatti, R.; Tarzia, G.; Battaglia, F.; Barone, D.; Baldoli, E.
Il Farmaco; Edizione Scientifica 43(12): 989-1003
1988
ISSN/ISBN: 0430-0920 PMID: 2854788 Document Number: 321094
The synthesis of a new class of potential angiotensin converting enzyme (ACE) inhibitors, analogs of enalapril, is reported. In these molecules the C-terminal amino acidic sequence Ala-Pro of enalapril was replaced by the sequence Pro-Pro. The compounds were tested both in vitro and in vivo. They showed no in vivo activity but only a week in vitro inhibitory activity.
Document emailed within 1 workday
Related Documents
Cecchi, R.; Ciabatti, R.; Favara, D.; Barone, D.; Baldoli, E. 1985: Imidazolyl derivatives of enalapril as potential angiotensin converting enzyme inhibitors Il Farmaco; Edizione Scientifica 40(8): 541-554Atlas, S.A.; Case, D.B.; Yu, Z.Y.; Laragh, J.H. 1984: Hormonal and metabolic effects of angiotensin converting enzyme inhibitors. Possible differences between enalapril and captopril American Journal of Medicine 77(2a): 13-17
Karlberg, B.E.; Fyhrquist, F.; Grönhagen-Riska, C.; Tikkanen, I.; Ohman, K.P. 1984: Enalapril and lisinopril in renovascular hypertension--antihypertensive and hormonal effects of two new angiotensin-converting-enzyme (ACE) inhibitors. A preliminary report Scandinavian Journal of Urology and Nephrology. Supplementum 79: 103-106
Bajaj, A.K. 1988: Enalapril: a second-generation angiotensin converting enzyme inhibitor American Journal of the Medical Sciences 296(5): 332-335
Rokicki, W.; Borowicka, E. 1997: Use of converting angiotensin inhibitors in children. II. Personal experience with enalapril Wiadomosci Lekarskie 50(4-6): 85-93
Mizuno, K.; Hashimoto, S.; Kunii, N.; Tani, M.; Niimura, S.; Yabe, R.; Watari, H.; Fukuchi, S. 1985: Acute effects of the new oral angiotensin converting enzyme inhibitor 1-(D-3-acetylthio-2-methylpropanoyl)-L-prolyl-L-phenylalanine (Alacepril) in essential hypertension Research Communications in Chemical Pathology and Pharmacology 49(2): 175-187
Ganten, D.; Mullins, J.; Lindpaintner, K. 1989: The tissue renin-angiotensin system: a target for angiotensin-converting enzyme inhibitors Journal of Human Hypertension 3(Suppl 1): 63-70
De Paz, S.; Martín, A.B.; Iglesias, A.; Domínguez, A.R. 1999: Angioedema-urticaria caused by angiotensin-converting enzyme inhibitors and angiotensin Ii receptor antagonists Medicina Clinica 113(19): 759
Jover, B.; Mimran, A. 1994: Angiotensin II receptor antagonists versus angiotensin converting enzyme inhibitors: effects on renal function Journal of Hypertension. Supplement: Official Journal of the International Society of Hypertension 12(9): S3-S9
Krzesinski, J.M.; Montrieux, C.; Scheen, A.J. 2006: Angiotensin converting enzyme inhibitors or angiotensin Ii receptor blocker in cardiovascular and renal pathology in 2006: what does EBM teach us? Revue Medicale de Liege 61(5-6): 414-422
Surabenjawong, U.; Thunpiphat, N.; Chatsiricharoenkul, S.; Monsomboon, A. 2013: Prevalence of hyperkalemia in adult patients taking spironolactone and angiotensin converting enzyme inhibitors or angiotensin receptor blockers Journal of the Medical Association of Thailand 96(8): 905-910
Wang, L.; Cai, S.-r.; Zhang, C.-h.; He, Y.-l.; Zhan, W.-h.; Wu, H.; Peng, J.-j. 2008: Effects of angiotensin converting enzyme inhibitors and angiotensin Ii receptor blockers on angiogenesis of gastric cancer in a nude mouse model Zhonghua Wei Chang Wai Ke Za Zhi 11(6): 565-568
Jasik, M.; Zdrojewicz, Z.; Stawicki, S. 1999: The activity of renin-angiotensin-aldosterone system (RAA) and possibilities of application angiotensin converting enzyme inhibitors (ACE I) in selected diseases of endocrine glands Wiadomosci Lekarskie 52(3-4): 202-210
Wang, L.; Cai, S.-r.; Zhang, C.-h.; He, Y.-l.; Zhan, W.-h.; Wu, H.; Peng, J.-j. 2008: Effects of angiotensin-converting enzyme inhibitors and angiotensin Ii type 1 receptor blockers on lymphangiogenesis of gastric cancer in a nude mouse model Chinese Medical Journal 121(21): 2167-2171
Humke, U.; Levens, N.; Wood, J.; Hofbauer, K. 1992: The acute renal actions of angiotensin converting enzyme inhibitors in the sodium-depleted conscious primate are mediated by inhibition of the renin-angiotensin system Journal of Pharmacology and Experimental Therapeutics 260(1): 29-35
Squire, I.B.; MacFayden, R.J.; Reid, J.L.; Devlin, A.; Lees, K.R. 1996: Differing early blood pressure and renin-angiotensin system responses to the first dose of angiotensin-converting enzyme inhibitors in congestive heart failure Journal of Cardiovascular Pharmacology 27(5): 657-666
Inzhutova, A.I.; Salmina, A.B.; Petrova, M.M. 2007: Pronounced homeostatic action of angiotensin converting enzyme inhibitors with high affinity to tissue renin-angiotensin-aldosterone system on cellular membranes Kardiologiia 47(8): 49-52
Abe, K. 1985: Angiotensin converting enzyme inhibitors Nihon Rinsho. Japanese Journal of Clinical Medicine 43(5): 949-955
Rizzoni, D. 1991: Angiotensin-converting enzyme inhibitors Recenti Progressi in Medicina 82(4): 251-252
Dipalma, J.R. 1980: Angiotensin-converting enzyme inhibitors American Family Physician 22(5): 164-165