Hyperthermic perfusion therapy using peplomycin for bladder cancer
Nakajima, K.; Hisazumi, H.; Misaki, T.; Sugata, T.; Koshida, K.; Saito, Y.; Naito, K.; Kameda, K.; Taya, T.; Miyazaki, K.
Hinyokika Kiyo. Acta Urologica Japonica 31(9): 1559-1563
1985
ISSN/ISBN: 0018-1994 PMID: 2417464 Document Number: 256368
Hyperthermic intravesical perfusion therapy using peplomycin (40 micrograms/ml) in distilled water at 43 degrees C as a perfusate was performed for 2 to 3 hours in 18 patients with superficial bladder tumors and 2 with deep bladder tumors. The therapeutic efficacy was determined by cystoscopy, ultrasonography and/or CT scan. Complete and partial tumor regression was obtained in 1 and 3 of the 18 patients, respectively. There was no tumor regression in the 12 patients. Most of the patients studied had bladder discomfort such as irritation, urinary frequency and so on, during and/or after perfusion. None of the patients developed acute pyelonephritis.