Effect of hyperthermic irrigation with bleomycin on prophylaxis of recurrence of bladder cancer
Nishimura, K.; Ogawa, O.; Yoshimura, N.; Nakagawa, T.; Sasaki, M.
Hinyokika Kiyo. Acta Urologica Japonica 31(5): 769-773
1985
ISSN/ISBN: 0018-1994 PMID: 2413744 Document Number: 246621
Hyperthermic irrigation with bleomycin of bladder at 43 .apprx. 44.degree. C for 3 h after operation was performed in about 80 cases of bladder cancer from 1978. Bleomycin (90 mg) in 3,000 ml saline solution was irrigated for 10 days postoperatively. No severe side effect was observed, while the complaint of a local side effect (bladder irritability) was made in 57.8%. Non-recurrence rate was calculated by the actual method, in 54 patients with bladder cancer which occurred initially. Non-recurrence rate was 88.0% after 1 yr, 73.3% after 2 and 3 yr and 63.5% after 4 yr or more. Recurrence rate per 100 patient-month was 0.98. It was concluded that hyperthermic irrigation with bleomycin was useful for the prophylaxis for recurrence of bladder cancer after removal of the tumor.