Levels of Cis-Platinum in hyperthermic isolated perfusion
Hild, P.; Aigner, K.; Henneking, K.
Anticancer Research 2(4): 255-256
1982
ISSN/ISBN: 0250-7005 PMID: 6890786 Document Number: 190598
The Cis-platinum levels in isolated extremity perfusion were measured in dogs and man. We found that prolonged presence of Cis-platinum in the tissue is attributed to its strong and rapid binding to serum and tissue proteins. Protein binding follows the concentration gradient. Subsequent re-diffusion into the blood followed by urinary excretion was also noted.
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