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Ochrolifuanines, alkaloid analogs of emetine and tubulosine: hemisynthesis and research on cytotoxic and antitumor properties

Seguin, E.; Trinh Minh Chau; Koch, M.; André, S.; Farjaudon, N.; Pareyre, C.; Tempête, C.; Robert-Géro, M.; Bourut, C.; Chenu, E.

Annales Pharmaceutiques Francaises 43(3): 301-310

1985

ISSN/ISBN: 0003-4509
PMID: 4083694
Document Number: 256357
Several ochrolifuanines, indole alkaloid analogs of emetine and tubulosine have been synthesized by PICTET-Spengler condensation between dihydrocorynantheal and various tryptamines. The study of the biological properties of these molecules (i.e.: determination of the cytotoxicity using the Allium test, effect on the growth of normal chick embryo fibroblasts, the transformation of these cells by Rous sarcoma virus and the effect on P 388 leukemia of mice) has established the expected cytotoxicity but has shown a lack of specificity towards tumor cells. The results are discussed in order to orient further synthesis to prepare more selective derivatives.

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Mirabelli, C.K.; Johnson, R.K.; Sung, C.M.; Faucette, L.; Muirhead, K.; Crooke, S.T. 1985: Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models Cancer Research 45(1): 32-39
Jones, B.R.; Ofosu, G.A. 1977: Cytotoxic effects of emetine hydrochloride in the kidney of Long-Evans rats Cytobios 19(74): 109-118
Ye, X-rong.; Chai, Y-hai.; Li, X-nan.; Wu, K-mei. 2004: Studies on the synthesis and antitumor activity of the derivatives of cephalotaxine alkaloid esters Yao Xue Xue Bao 39(6): 429-433
Hrabowska, M.; Ledóchowski, A.; Stefańska, B.; Onoszko, K. 1970: A search for antitumor compounds. 8. Biologic studies. Antitumor properties of 17 new 1-nitro-9-aminoacridine derivatives Archivum Immunologiae et Therapiae Experimentalis 18(5): 557-570
Alunni-Bistocchi, G.; Orvietani, P.; Bittoun, P.; Ricci, A.; Lescot, E. 1993: 2,4-Dimethyl-6 H-pyrido[3,2-b]carbazole, an isomer of the antitumor alkaloid ellipticine via the Combes-Beyer reaction Die Pharmazie 48(11): 817-820
Hrabowska, M.; Ledóchowski, A.; Wysocka-Skrzela, B.; Onoszko, K.; Paradziej-Lukowicz, J. 1981: Search for antitumor compounds. XIII. Biological studies. Antitumor properties of 20 quinolines, carbazoles, acridines nitro derivatives Archivum Immunologiae et Therapiae Experimentalis 29(2): 205-216
Rose, W.C.; Schurig, J.E.; Huftalen, J.B.; Bradner, W.T. 1982: Antitumor activity and toxicity of cisplatin analogs Cancer Treatment Reports 66(1): 135-146
Inaba, M.; Nagashima, K.; Sakurai, Y.; Fukui, M.; Yanagi, Y. 1984: Reversal of multidrug resistance by non-antitumor anthracycline analogs Gan 75(12): 1049-1052
Inaba, M.; Nagashima, K.; Sakurai, Y.; Fukui, M.; Yanagi, Y. 1984: Reversal of multidrug resistance by non-antitumor anthracycline analogs Gan 75(12): 1049-1052
Flora, K.P.; van't Riet, B.; Wampler, G.L. 1978: Antitumor activity of amidoximes (hydroxyurea analogs) in murine tumor systems Cancer Research 38(5): 1291-1295
Zhukova, G.v.; Shikhliarova, A.I.; Soldatov, A.V.; Barteneva, T.A.; Petrosian, V.I.; Gudtskova, T.N.; Bragina, M.I.; Polozhentsev, O.E.; Sheiko, E.A.; Maschenko, N.M.; Shirnina, E.A.; Zlatnik, E.Y.; Kurkina, T.A. 2016: Some Approaches to Activation of Antitumor Resistance Mechanisms and Functional Analogs in Categories of Synergetics Biofizika 61(2): 359-373
Sawada, M.; Ozaki, M.; Hongo, J.; Hirota, Y.; Inagaki, M.; Taniguchi, H.; Tateishi, R.; Mori, Y. 1987: Antitumor activity of platinum analogs against human ovarian tumors heterotransplanted into nude mice Gan to Kagaku Ryoho. Cancer and ChemoTherapy 14(3 Part 1): 693-698
Grindey, G.B.; Divekar, A.Y.; Hakala, M.T. 1973: Antitumor activity of N6-phenyladenosine, and inhibitor of adenosine utilization, in combination with related purine analogs Cancer Research 33(10): 2459-2463
Sengupta, M.; Sengupta, O. 1995: Correlation of biological activity (therapeutic and toxic) with solvochromic properties of metronidazole, emetine hydrochloride and diloxanide furoate Indian Journal of Biochemistry and Biophysics 32(5): 302-307
Varnavas, A.; Nisi, C.; Lassiani, L.; Sava, G.; Perissin, L.; Boccù, E. 1991: Synthesis and antitumor activity of hydrosoluble analogs of p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt Arzneimittel-Forschung 41(11): 1168-1172
Kleinrok, Z.; Jagiełło-Wójtowicz, E.; Matuszek, B.; Chodkowska, A. 1992: Basic central pharmacological properties of thiophosphoric acid alkaloid derivatives from Chelidonium majus L Polish Journal of Pharmacology and Pharmacy 44(3): 227-239
Albert, O.; Dupont, M.; Quirin, M. 1970: Studies on some pharmacodynamic properties of an indole alkaloid: dregamine. Action on the nervous and muscular systems Annales Pharmaceutiques Francaises 28(12): 697-706
Bielat, K.L.; Halpern, J.; Simich, J.P.; Huben, R.P.; Ambrus, J.L. 1988: A morphological analysis of an in vitro model of cytotoxic antitumor activity Cancer Detection and Prevention 12(1-6): 1-7
Wang, Y.; Perchellet, E.M.; Ward, M.M.; Lou, K.; Zhao, H.; Battina, S.K.; Wiredu, B.; Hua, D.H.; Perchellet, J.-P.H. 2006: Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria International Journal of Oncology 28(1): 161-172
Gautam, S.; Chikkala, N.; Ganapathi, R. 1992: Immunomodulation by adriamycin - effect on the production of cytotoxic and inflammatory antitumor immune-responses International Journal of Oncology 1(7): 799-805