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Antitumor activity of amidoximes (hydroxyurea analogs) in murine tumor systems

Flora, K.P.; van't Riet, B.; Wampler, G.L.

Cancer Research 38(5): 1291-1295

1978

ISSN/ISBN: 0008-5472
PMID: 639062
Document Number: 136763
A series of amidoximes was prepared and evaluated for possible antitumor activity against L1210 leukemia. Three of the most active compounds in the L1210 system, formamidoxime, acetamidoxime, and 2-aminoacetamidoxime hydrochloride, were also active against P388 leukemia. Acetamidoxime was marginally active against Lewis lung carcinoma. The active amidoximes showed best activity against L1210 leukemia when given two times daily, 5 hours apart, for 8 days. Most of the amidoximes produced excessive central nervous system stimulation.

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