Cyclohexylphenoxy amidoximes and imidazolines with antidepressive and alpha-adrenergic activity
Picciòla, G.; Carissimi, M.; Ravenna, F.; Gentili, P.; Carenini, G.
Arzneimittel-Forschung 29(5): 729-738
1979
ISSN/ISBN: 0004-4172 PMID: 40574 Document Number: 140371
The effect of variation of the cycloaliphatic residue position on pharmacological activity was studied in two series of cyclohexylphenoxy derivatives (A and B). (Formula: See text) The ortho derivatives generally exhibit remarkably strong activity; (A) has an imipramine-like pharmacological profile; (B) with Y = H is more active than naphazoline and xylomethazoline as vasoconstrictor. The meta and para substituted derivatives and all (B) derivatives with R = CH3 exhibited no definite or interesting pharmacological activities.