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Effect of insulin on an insulin receptor of PLC/PRF/5 human hepatoma cell line

Testa, I.; Clementi, M.; Festa, A.; Bagnarelli, P.; Brugia, M.; de Martinis, C.

Developments in Biological Standardization 60: 81-91

1985

ISSN/ISBN: 0301-5149
PMID: 2995179
Document Number: 255113
A human hepatoma cell line (PLC/PRF/5) contains several copies of hepatitis B virus (HBV) DNA in integrated form and releases hepatitis B surface antigen (HBsAg) in the form of 22 nm particles in culture medium; studies of the supernatant fluid failed to provide evidence of the morphologically intact virion (Dane particle) or hepatitis B infectivity. In this paper we describe the effect of insulin on cell growth and HBsAg production by these cells; moreover we describe the insulin binding to specific cell membrane receptors. Data in our hands point to a different insulin binding related to different incubation conditions.

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