Rapid diagnosis of dysbacteriosis by detecting beta-aspartylglycine in the feces in an experiment
Chakhava, O.V.; Ruban, S.Z.; Shustrova, N.M.; Iur'eva, E.A.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 8: 15-18
1985
ISSN/ISBN: 0372-9311 PMID: 4060948 Document Number: 254329
In experiments on Fischer rats (F-344), both with common microflora and germ-free, the influence of the systemic destination of different antibiotics (tetracycline + ampicillin, gentamicin + kefzol, gentamicin, fradizine) on the intestinal microflora, the content of beta-ospartylglycine in feces and the colonization resistance of the intestinal tract to Staphylococcus aureus B-243 and Pseudomonas aeruginosa No. 93 has been studied. The early appearance of beta-aspartyl-glycine in the supernatant of fecal samples has been shown to be the first sign of dysbacteriosis and to indicate the decrease of the colonization resistance of the intestine to opportunistic bacteria.