Combination chemotherapy with peplomycin, cis-platinum and mitomycin C in gynecologic cancer
Yasui, Y.; Suzumori, K.; Asai, H.; Yagami, Y.
Gan no Rinsho. Japan Journal of Cancer Clinics 31(11): 1415-1421
1985
ISSN/ISBN: 0021-4949 PMID: 2415720 Document Number: 252443
Eight patients with gynecologic cancer (cervix: 6, corpus: 1 and vulva: 1) were treated with combination chemotherapy, PPM therapy consisting of continuously infused PEP 4mg/m2 days 1-5, CDDP 13 mg/m2 days 1-5, and MMC 3mg/m2 day 1. This was repeated every three to five weeks. Six of the eight patients were evaluable, two had a complete response and one had a partial response, for an overall response rate of 50%. Because of hematological toxicity, blood transfusion was carried out in four patients. Nephrotoxicity and pulmonary toxicity were slight. Nausea and vomiting were controlled with dexamethasone and domperidone. PPM therapy is considered to be an effective and useful combination chemotherapy for patients with gynecologic cancer.