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Clinical and histological effect of induction chemotherapy with peplomycin, vincristine, mitomycin C and cis-platinum on oral squamous cell carcinomas

Shirasuna, K.; Ogura, T.; Mima, T.; Hiranuma, T.; Sakai, T.; Hayashido, Y.; Matsuya, T.; Usui, M.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 22(1): 53-58

1995

ISSN/ISBN: 0385-0684
PMID: 7826078
Document Number: 446243
Twenty one patients with resectable oral cancer received two courses of induction chemotherapy with peplomycin (PEP), vincristine (VCR), mitomycin C (MMC) and cisplatin (CDDP). Five patients had a complete response to the therapy and 9 had a partial response. Histological evaluation by Ohboshi-Shimozato classification indicated that Grade IV was obtained in 7 cases, Grade III was in 4 cases. Moreover, the study suggested that this regimen was less effective for metastatic lymph lesions than that for the primary tumors.

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