Circadian changes of gluconeogenic enzymes in irradiated rats
Paulíková, E.; Ahlers, I.; Praslicka, M.
Physiologia Bohemoslovaca 34(4): 351-357
1985
ISSN/ISBN: 0369-9463 PMID: 2997820 Document Number: 251859
The authors studied in the effect of whole body irradiation at different times of day on the circadian rhythms of gluconeogenic enzymes. They found that: 1. liver and kidney enzyme activities were highest in the light part of the day and lowest in the middle of the dark part; 2. 12-h circadian rhythm of glucose-6-phosphatase and fructose-1,6-bisphosphatase activity in the liver and the renal cortex followed a similar course; 3. a lethal whole body dose of 14.4 Gy X-rays did not affect the circadian oscillation curves of the given enzymes, with the exception of fructose-1,6-bisphosphatase in the liver of irradiated rats, where the rhythm was lost.