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Spectrophotometric analysis of mixtures of acetaminophen, salicylamide, and codeine phosphate in tablets

El Kheir, A.A.; Belal, S.F.; el Shanwani, A.

Journal - Association of Official Analytical Chemists 68(5): 1048-1050

1985

ISSN/ISBN: 0004-5756
PMID: 4055623
Document Number: 250254
A simple and accurate spectrophotometric procedure for the analysis of a mixture of acetaminophen, salicylamide, and codeine phosphate is described. Determination of the first 2 components depends on pH-induced differential spectral changes of their nitroso derivatives. The third component is assayed by the acid dye method. The proposed procedure was successfully applied to the analysis of laboratory-made and commercial tablets containing the ternary drug mixture.

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