Meiosis II, mitosis i and the linking interphase: a study of the cytoskeleton in the fertilised mouse egg
Howlett, S.K.; Webb, M.; Maro, B.; Johnson, M.H.
Cytobios 43(174s): 295-305
1985
ISSN/ISBN: 0011-4529 PMID: 4075850 Document Number: 247479
Data concerning the organisation and the role of microtubules and microfilaments during the 20 h following fertilisation in vitro of the mouse oocyte is reviewed. This period covers the fertilisation-induced completion of meiosis, from second meiotic metaphase through the first mitotic cell cycle, and involves the union of the haploid parental genomes. Various antibodies were used against actin, tubulin and PCM to describe the localisation of the cytoskeletal components and the two cytoskeleton-disrupting drugs nocodazole and CCD to assess the functional importance of the cytoskeleton.