Role of adrenergic structures in regulating the release by the intestines of hemocoagulating compounds into the blood stream
Golyshenkov, S.P.; Skipetrov, V.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 99(3): 265-266
1985
ISSN/ISBN: 0365-9615 PMID: 2985146 Document Number: 243822
Experiments on cats were made to study the capability of adrenaline, tropaphen and propranolol of influencing the intensity of the release of hemocoagulating compounds and anticoagulants from the intestinal vessels and tissues to the bloodstream (perfusate). Adrenaline was found to increase the coagulative activity of the perfusate, provoking an enhanced release into it of thromboplastin, an analogue of plasma factor V and antiheparin compounds and suppressing the release of antithromboplastins. The blockade of the alpha-adrenoreceptors was accompanied by a dramatic increase of antithromboplastins to the intestinal perfusate, whereas the depression of the activity of beta-adrenergic structures by reduction of the release of tissue thromboplastin inhibitors. It is concluded that regulation of the release of antithromboplastins in the intestine is mediated by the structures similar in their characteristics to alpha- and beta-adrenoreceptors.