Rates of endogenous noradrenaline release in rat brain, heart and intestines: comparison of results obtained after biosynthesis inhibition and 3H-tyrosine labeling
Rochette, L.; Bralet, J.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 169(1): 80-85
1975
ISSN/ISBN: 0037-9026 PMID: 126752 Document Number: 92320
After labelling of noradrenaline stores with tyrosine 3H, the rate constant of NA efflux was calculated from the change of the NA-3H and TY-3H specific activities. The biological half-life of NA was 2,2 h in the brain, 24 h in the heart and 3,3 h in the intestine. These values were similar to those obtained after inhibition of NA synthesis by alpha-methylparatyrosine.
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