Synthesis of 2'-end-modified 2'-5'-oligoadenylates
Hayakawa, Y.; Nobori, T.; Noyori, R.
Nucleic Acids Symposium Series 16: 129-132
1985
ISSN/ISBN: 0261-3166 PMID: 4088856 Document Number: 242553
Analogs of 2'5'-oligiadenylates (2-5As) have been prepared on the basis of the recently developed internucleotide-linkage formation via selective hydroxyl activation of N-unprotected nucleosides. The analogs synthesized include the trimeric cores having 2'-deoxyadenosine, cordycepin (3'-deoxyadenosine), and 2',3'-bisdeoxyadenosine at the 2' termini, and the tetramer with 2'-end 2'-deoxyadenosine.
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