Effect of dietary treatment on the plasma levels of lipids, lipoprotein cholesterol and LDL B protein in children with type Ii hyperlipoproteinemia
Kwiterovich, P.O.; Bachorik, P.S.; Franklin, F.A.; Margolis, S.; Georgopoulos, L.; Teng, B.; Sniderman, A.D.
Progress in Clinical and Biological Research 188: 123-137
1985
ISSN/ISBN: 0361-7742 PMID: 4059254 Document Number: 242040
These data confirm the effectiveness of therapeutic diets in children with type II hyperlipoproteinemia in conventional terms. However, the decrease in LDL cholesterol was not accompanied by a significant decrease in LDL B (suggesting only a small change in the number of LDL particles in plasma), and a fall in HDL cholesterol occurred, with no significant improvement in the LDL to HDL cholesterol ratio. These findings indicate that further research is needed to develop diets with more optimal effects. Finally, our hypothesis that such diets may produce an LDL particle of altered composition, needs to be confirmed using additional physical-chemical measurements of the size, composition and molecular weight distribution of LDL in plasma before and after dietary intervention.