In vitro biocompatibility: increase in the capacity for adhesion in fibroblasts by materials pretreated with fibronectin
Cannas, M.; Amedeo, M.R.; Sibelli, P.
Bollettino della Societa Italiana di Biologia Sperimentale 60(10): 1913-1917
1984
ISSN/ISBN: 0037-8771 PMID: 6518101 Document Number: 241867
The Authors expose their observations about the fibroblasts adhesion to materials used as implants in orthopaedic surgery; the first part of the experiment uses normal culture conditions. In the second part the materials have been pre-coated with Fibronectin (FN), a glycoprotein involved in cell-to-substratum adhesion Fibroblasts adhesion increases about 30-40% with pre-coated materials. This observation is important for comprehension of adhesion mechanisms in a multidisciplinary approach to biocompatibility of implant materials.