Dietary sodium intake and vasopressin excretion in man
Kjeldsen, S.E.; Forsberg, G.; Eide, I.; Aakesson, I.; Os, I.; Skjøtø, J.; Frederichsen, P.
Journal of Hypertension. Suppl Official Journal of the International Society of Hypertension 2(3): S301-S303
1984
ISSN/ISBN: 0952-1178 PMID: 6599675 Document Number: 241759
The present study was undertaken to examine the possible relationship between dietary sodium intake and arginine vasopressin (AVP). In 12 normotensive men (aged 23-26 years) urinary AVP excretion decreased from 6.7 +/- 1.0 to 3.9 +/- 0.3 ng/h (P less than 0.01) when sodium excretion by dietary intervention for one week was reduced from 188 +/- 18 to 16 +/- 2 mmol/24 h. At a high sodium intake (300 mmol/day), AVP excretion increased to 10.0 +/- 1.2 ng/h during the first day (P less than 0.01) and remained high throughout one week of sodium load. These results are compatible with a major physiological role of sodium in AVP secretion in man. A sodium-AVP relationship may play a role in the pathogenesis of essential hypertension since recent reports suggest elevated plasma AVP in essential hypertensive states.