Characteristics of the effect of haloperidol and clozapine on the rhythmic features of phenamine sterotypy in cats
Tolpyshev, B.A.; Arushanian, E.B.
Farmakologiia i Toksikologiia 47(6): 20-25
1984
ISSN/ISBN: 0014-8318 PMID: 6542875 Document Number: 240451
Experiments on cats with the use of an electromechanical rotameter enabling one to separately record head turns to the right and to the left were made to examine the action of the neuroleptics on the time-course of changes in the horizontal component of amphetamine stereotypy. It was shown that haloperidol which destabilizes the oscillatory curve of the rate of head turns led to a progressive decrease in the number of movements. Clazapine also destabilized the rhythmic process. However, increasing the amplitude of oscillations the drug made the curve phasic in nature. Both the neuroleptics caused synchronization of the oscillation rate of head turns to the right and to the left.