Effect of phenamine and gutimine and gutimine on adaptive changes in arterial pressure occurring during skeletal muscle contraction
Medvedev, O.S.; Stepochkina, N.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 80(12): 41-44
1975
ISSN/ISBN: 0365-9615 PMID: 1225398 Document Number: 93227
Effects of amphetamine (0,1--11 mg/kg) and gutimin (5--50 mg/kg) on the pressor reflex originating in the exercising muscle were studied on nonanesthetized decerebrate cats. Isometric exercise of the hind limb muscles was elicited by stimulating the spinal ventral roots L6--S1. Amphetamine (0.1 mg/kg) increased the level of arterial pressure and the amplitude of the pressor reflex. Higher doses of amphetamine decreased the pressor reflex to exercises and there was a fall of arterial pressure. Gutimin elevated the arterial pressure and failed to alter the pressor reflex to exercises.