Critical tests of activity of dl-tetramisole against the internal parasites of horses
Lyons, E.T.; Drudge, J.H.
American Journal of Veterinary Research 31(8): 1477-1480
1970
ISSN/ISBN: 0002-9645 PMID: 5449902 Document Number: 23828
Single doses of tetramisole were evaluated in nine critical tests with horses (2.2, 5 and 10 mg/kg given s/c and 20 and 30 mg/kg given by mouth). Parascaris equorum was removed (83 to 100%) by all of the doses, and 98% of Strongylus vulgaris were removed by the two largest doses. The largest doses removed only 38-54% of S. edentatus, while the dose of 30 mg/kg removed 74% of small strongyles. Results against mature Oxyuris equi were variable, and only 13% of immature oxyurids were removed at 30 mg/kg. There was no effect on Gastrophilus intestinalis and G. nasalis. Toxicosis occurred only in the horse given 30 mg/kg, characterized by hyperexcitability, sweating and lacrima-tion, and lasted about 6 hours.