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Comparative studies of the effect of mithramycin and calcitonin on small intestine and pancreas function in the rat

Heuer, L.J.; Wassmann, L.; Wood, W.G.

Deutsche Zeitschrift für Verdauungs- und Stoffwechselkrankheiten 44(2): 45-49

1984

ISSN/ISBN: 0012-1053
PMID: 6236968
Document Number: 235048
The effects of synthetic salmon calcitonin (Calcitonin R-Sandoz) at a dose of 10 IU/kg BW and Mithramycin (Mithramycin R-Pfizer) at a dose of 35 micrograms/kg BW on the absorption of calcium was evaluated in normocalcenic fasted rats by investigating both the pancreatic function and the intestinal absorption of xylose. During 2 h observation calcitonin induced a fall in serum calcium concentration of 6 % (p = n.s.). As compared with controls, the renal elimination of xylose is diminished in calcitonin treated animals by 49% (p less than 0,1), whilst in mithramycin treated animals no change is observed. Serum insulin level was not influenced by calcitonin, but it was stimulated about 70% (p less than 0,05) by mithramycin. Blood glucose concentration is decreased only by 14 mg % (calcitonin) and 18 mg % mithramycin) (p = n.s.). Both drugs do change neither urinary volume nor serum alpha-Amylase. It is concluded that the sites of action of mithramycin differ from those of calcitonin.

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