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Adrenoceptor mechanisms in the regulation of contractile activity in the human cervix

Bryman, I.; Lindblom, B.; Norström, A.; Sahni, S.

Obstetrics and Gynecology 64(3): 363-367

1984

ISSN/ISBN: 0029-7844
PMID: 6146956
Document Number: 234529
The effects of adrenoceptor agonists and antagonists on the contractile activity of cervical strips from early pregnant and nonpregnant women were studied. Noradrenaline and the .alpha.-adrenoceptor agonist, phenylephrine, had a stimulatory effect on smooth muscle activity. This response could be blocked totally by the .alpha.-adrenoceptor antagonist, phenoxybenzamine. Isoprenaline, known to be a .beta.-adrenoceptor agonist with some .alpha.-adrenoceptor activity, had stimulatory and inhibitory effects, whereas the .beta.2-adrenoceptor agonist, terbutaline, exhibited a pure inhibitory action. The inhibitory effects of isoprenaline and terbutaline were totally blocked by the .beta.-adrenoceptor antagonist propranolol. In pregnant patients, the sensitivity to noradrenaline was significantly higher and the inhibitory action of terbutaline was less pronounced, which indicated the predominance of .alpha.-receptor activity in the uterine cervix during pregnancy.

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Shirinskiĭ, V.P. 1999: Molecular mechanisms of regulation of the contractile apparatus of smooth muscles Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 85(6): 798-812
Bengtsson, B. 1982: Factors of importance for regulation of uterine contractile activity Acta Obstetricia et Gynecologica Scandinavica. Supplement 108: 13-16
Kapilevich, L.V.; Baskakov, M.B.; Medvedev, M.A.; Petrov, E.I.; Kuskov, M.V.; Timofeev, V.I.; Kovalev, I.V. 1995: Dependence of the regulation of tracheal smooth muscle contractile activity on epithelium Biulleten' Eksperimental'noi Biologii i Meditsiny 119(3): 283-285
MacEwan, D.J.; Milligan, G. 1996: Inverse agonist-induced up-regulation of the human beta2-adrenoceptor in transfected neuroblastoma X glioma hybrid cells Molecular Pharmacology 50(6): 1479-1486
Ghatta, S.; Srinivasan, K.; Kaul, C.L.; Ramarao, P. 2005: A study on alpha-adrenoceptor mediated contractile responses of high fat diet fed rat thoracic aorta Die Pharmazie 60(2): 142-146
Vornovitskiĭ, E.G.; Ignat'eva, V.B.; Marchuk, A.I.; Len'kova, N.A. 1987: Intensification of human myocardial contractile activity as affected by blood serum Biulleten' Eksperimental'noi Biologii i Meditsiny 103(3): 279-281
Besse, P.; Terrasson, C.; Choussat, A.; Broustet, J.P.; Bricaud, H. 1971: Mechanical and contractile properties of human myocardium. II. Contractile properties of normal human cardiac muscle Archives des Maladies du Coeur et des Vaisseaux 64(4): 485-500
Minasian, S.M.; Baklavadzhian, O.G.; Adamian, T.I.; Saakian, S.G.; Gulian, V.S. 1995: Cortical mechanisms of regulation of neuron activity of Deiters vestibular nucleus during vibration Aviakosmicheskaia i Ekologicheskaia Meditsina 29(6): 32-35
Karpov, B.A.; Karpova, A.N.; Viktorov, I.T. 1973: Several mechanisms of disorders of the regulation of optomotor components of cognitive activity in lesions of the frontal lobe in man Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 73(12): 1841-1847
Namazi, M.R. 2008: The molecular mechanisms of down-regulation of expression and activity of inducible nitric oxide synthase in the psoriatic lesions Nigerian Journal of Medicine: Journal of the National Association of Resident Doctors of Nigeria 17(4): 465-466
Krauz, V.A.; Kushchinskaia, A.I.; Drozdov, A.A.; Perevoznik, N.V. 1982: Role of cholinergic mechanisms in the regulation of ATPase activity and the intensity of glycolysis in the rat neocortex, hippocampus and brain stem Farmakologiia i Toksikologiia 45(2): 22-26
Cheknev, S.B. 1999: Functional organization and mechanisms of human intrinsic regulation of natural cytotoxicity system Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 10: 37-40
Zhao, P.-W.; Lee, D.Y.-W.; Ma, Z.-Z.; Sun, Y.-L.; Tao, S.-Y.; Zang, J.-F.; Niu, J.-Z. 2014: Effect of carnosol against proliferative activity of breast cancer cells and its estrogen receptor subtype's mediation and regulation mechanisms Zhongguo Zhong Yao Za Zhi 39(17): 3344-3348
Brandt, M.E.; Krueger, G.R.F.; Wang, G.; Buja, L.Maximilian. 2004: Feed-forward and feedback mechanisms in a dynamic model of human T cell development and regulation In Vivo 18(4): 465-470
Takahashi, K.; Hayashi, N.; Kaminogawa, S.; Ra, C. 2006: Molecular mechanisms for transcriptional regulation of human high-affinity IgE receptor beta-chain gene induced by GM-CSF Journal of Immunology 177(7): 4605-4611
Dollery, C.T. 1976: Centrally acting alpha-adrenoceptor agonists in hypertension: mechanisms and their role in therapy Australian and New Zealand Journal of Medicine 6(3): 88-94
Chester, M.R.; Barnett, D.B. 1995: Cardiac chamber-specific beta-adrenoceptor regulation and sympathetic innervation Lancet 345(8949): 553-555
Ianchuk, P.I.; Prykhod'ko, T.P.; Pasichnichenko, O.M.; Tieriekhov, A.A.; Tsybenko, V.O. 2011: Mechanisms of contractile action of acetylcholine on hepatic veins Fiziolohichnyi Zhurnal 57(1): 21-28
Winegrad, S.; McClellan, G.; Horowits, R.; Tucker, M.; Lin, L.E.; Weisberg, A. 1983: Regulation of cardiac contractile proteins by phosphorylation Federation Proceedings 42(1): 39-44
Maroto, R.; Calvo, S.; Sancho, C.; Esquerro, E. 1992: Alpha- and beta-adrenoceptor cross-talk in the regulation of glycogenolysis in dog and guinea-pig liver Archives Internationales de Pharmacodynamie et de Therapie 317: 35-46