Feed-forward and feedback mechanisms in a dynamic model of human T cell development and regulation
Brandt, M.E.; Krueger, G.R.F.; Wang, G.; Buja, L.Maximilian.
In Vivo 18(4): 465-470
2004
ISSN/ISBN: 0258-851X PMID: 15369186 Document Number: 575903
We describe a computational model of human T cell regulatory dynamics. We used this model to simulate changes in T cell pool numbers and for studying feedback and feed-forward responses in and among these pools. The pools identified were the bone marrow stein cell compartment, early and late thymocyte compartments and the peripheral compartment of mature T lymphocytes. Simulated data showed variable intercompartmental strengths indicative of a range of sensitivities to feedback regulation and respective variable feed-forward responses. The results compare well to known clinical and experimental data, rendering the computational model a good basis for further research in T cell development and regulation.