In vitro synergism of nalidixic acid with other broad spectrum antibiotics
Piccolomini, R.; Cellini, L.; Allocati, N.; Ravagnan, G.
Chemioterapia International Journal of the Mediterranean Society of ChemoTherapy 3(2): 103-107
1984
ISSN/ISBN: 0392-906X PMID: 6532536 Document Number: 233997
In vitro studies of the activity of antibiotic combinations in the ratio 1:1: nalidixic acid plus cephaloridine, nalidixic acid plus kanamycin and nalidixic acid plus erythromycin were performed by using an agar dilution technique with Mueller-Hinton Agar. Of 156 Enterobacteriaceae tested, nalidixic acid plus cephaloridine were synergistic for 96 (61.5%) strains compared with 101 (64.7%) with nalidixic acid plus kanamycin (P less than 0.01) and 85 (54.5%) with nalidixic acid plus erythromycin (P less than 0.001). These data suggest these combinations as possible effective tools in clinical trials, especially directed toward high level resistant urinary tract pathogens.