Beta-Galactosidase and neuraminidase deficiency associated with angiokeratoma corporis diffusum
Ishibashi, A.; Tsuboi, R.; Shinmei, M.
Archives of Dermatology 120(10): 1344-1346
1984
ISSN/ISBN: 0003-987X PMID: 6435542 Document Number: 231209
A 17-year-old Japanese boy was found to have ataxia, generalized angiokeratomas, skeletal deformities, visual impairment, and macular cherry-red spots, without hepatomegaly, splenomegaly, or renal failure. Laboratory examination disclosed a deficiency of beta-galactosidase as well as of neuraminidase activity in the leukocytes and fibroblasts, while alpha-galactosidase and alpha-L-fucosidase activities were normal. On electron microscopic examination, numerous cytoplasmic vacuoles containing flocculated material were found in the vascular endothelial cells, histiocytes, perineurial cells, and Schwann's cells.