Aminopeptidase activity in the livers of rats with experimental chronic renal failure
Ogura, M.; Hazato, T.; Katayama, T.
Biochemistry International 9(5): 621-624
1984
ISSN/ISBN: 0158-5231 PMID: 6525198 Document Number: 230940
Membrane-bound aminopeptidase activities in livers of rats with experimental renal failure were assayed. Only aminopeptidase A activity was decreased with the reduction in renal function, but aminopeptidase B and Leu-aminopeptidase activity did not change. The liver membrane-bound aminopeptidase A activity was inhibited by the addition of angiotensin I or -II in the enzyme assay system. From these results, it is expected that a decrease in liver membrane-bound aminopeptidase A activity may play a role in increasing angiotensin II during renal failure.