Inhibition by heparin of platelet accumulation in vivo
Barrett, P.A.; Butler, K.D.; Morley, J.; Page, C.P.; Paul, W.; White, A.M.
Thrombosis and Haemostasis 51(3): 366-370
1984
ISSN/ISBN: 0340-6245 PMID: 6495256 Document Number: 230916
In vivo -acether or thrombin. High doses of heparin were found to inhibit platelet accumulation induced by ADP, collagen or PAF-acether. Inhibition of these responses necessitated doses of heparin in excess of those required for anti-coagulant effects. The present experiments do not establish a mechanism for such inhibition. Extension to other species, including man, is needed before attributing clinical relevance to the present observations.
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