Clearance and in vivo release by heparin of human platelet factor 4 (PF4) in the rabbit
Prosdocimi, M.; Scattolo, N.; Zatta, A.; Fabris, F.; Stevanato, F.; Girolami, A.; Cella, G.
Thrombosis and Haemostasis 52(2): 157-159
1984
ISSN/ISBN: 0340-6245 PMID: 6523432 Document Number: 236120
13 male New Zealand rabbits were injected with two different doses (25 micrograms/Kg and 100 micrograms/Kg) of human platelet factor 4 antigen (PF4). The disappearance of the protein was extremely fast with an half-life for the fast component of 1.07 +/- 0.16 and 1.76 +/- 0.11 min respectively. The half-life for the slow component, detectable only with the highest dosage, was 18.8 min. The administration of 2500 I.U. of heparin 30 min after PF4 administration induced a partial release of the injected protein and its clearance from plasma was slow, with half-life of 23.3 +/- 5.9 min and 30.9 +/- 2.19 min respectively.