Oxygen-carrying substitutes other than fluorochemicals
Berré, J.; Dufaye, P.
Acta Anaesthesiologica Belgica 35 Suppl: 79-89
1984
ISSN/ISBN: 0001-5164 PMID: 6516762 Document Number: 229309
Beside the fluorochemicals, the research for oxygen carrying blood substitutes is pursued in two directions: hemoglobin derivatives and oxygen-binding chelates. Trials with hemoglobin had to overcome the following difficulties: renal toxicity, leakage outside the intravascular compartment, high affinity for oxygen and intravascular clotting effects. For several of these untoward effects, a satisfactory correction has been found. Other substances studied for possible oxygen-carrying fluids are various metal chelates. Several of these appear to be promising compounds, whereas no chelate is yet ready for in vivo investigation.