Analgesic activity and toxicity of potent analgesics, ohmefentanyl and mefentanyl
Huang, Z.M.; Zhou, J.; Chen, X.J.; Zheng, W.J.; Zhang, H.P.; Chi, Z.Q.; Li, Z.G.; Chen, W.L.
Zhongguo Yao Li Xue Bao 5(3): 153-158
1984
ISSN/ISBN: 0253-9756 PMID: 6239505 Document Number: 228518
The analgesic potency and the duration ohmefentanyl were found. The therapeutic indices (LD50/ED50) of OMF and MF were 5562 and 1159 in mice and 61.0 and 29.3 in rabbits, respectively. The toxic responses of OMF and MF on rabbits were effectively antagonized by nalorphine.
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