Genetic analysis of the susceptibility to neurological manifestations in spinal osteochondrosis
Ritsner, M.S.; Shmidt, I.R.; Karas', S.I.
Genetika 20(8): 1380-1386
1984
ISSN/ISBN: 0016-6758 PMID: 6541610 Document Number: 227824
Complex genetic-mathematical analysis (component decomposition of the phenotype variance, segregation analysis, estimation of penetrance parameters) of 324 probands' families with neurologic manifestation of spinal osteochondrosis (3437 relatives of I-III degree) has been carried out is shown that the structure of liability to the disease studied is better approximated by semi-continuous phenotype model within the limits of which contribution of genetic factors reaches 80% (63-66% owing to autosomes and 14-17% owing to gonosomes) under considerable influence (20%) of environmental force (14% accidental and 6% systematic).