Analysis of morphological manifestations of the inflammatory reaction in wistar rat spinal cord in experimental model
Gilerovich, E.G.; Fedorova, E.A.; Abdurasulova, I.N.; Karpenko, M.N.; Sokolov, A.V.; Zakharova, E.T.; Zhitnukhin, I.L.; KorzhevskiÄ, D.É; Vasil'ev, V.B.
Morfologiia 137(5): 16-20
2010
ISSN/ISBN: 1026-3543 PMID: 21500426 Document Number: 640242
Morphological changes in the spinal cord of rats with different intensity of pathological symptoms were studied at the peak of the experimental encephalomyelitis development. Light-microscopical and immunohistochemical methods were used. Distribution of proliferating cell nuclear antigen (PCNA), astrocyte marker - glial fibrillar acidic protein (GFAP), and microglia and macrophage marker Iba-1, was studied. Heterogeneity in morphological manifestations of the experimental allergic encephalomyelitis was shown. Four typical patterns of morphological manifestations of the disease were demonstrated depending on the preferential involvement of pia mater, vessels, spinal cell nuclei or conductive tracts in the pathological process.