Top Abstract Purchase Related
Home
>
Node
>
Subnode

Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat

Rivlin, A.S.; Tator, C.H.

Surgical Neurology 10(1): 38-43

1978

ISSN/ISBN: 0090-3019
PMID: 684604
Document Number: 128057
The effect of duration of acute compression of the spinal cord was assessed in a new model in the rat. The spinal cord was acutely compressed for varying times by a modified aneurysm clip which produced a compression force of 180 grams. The effect of duration of compression was measured by the inclined plane method of assessing the animals' clinical performance. The results showed a linear relationship between log compression time and clinical performance. Thus, the clinical effect of acute compression of the spinal cord injury is inversely related to duration of compression time and the relationship has been precisely quantified. These results suggest that persisting compression should be relieved as soon as possible in order to improve recovery.

Document emailed within 1 workday
Secure & encrypted payments

Bracken, M.B.; Shepard, M.J.; Holford, T.R.; Leo-Summers, L.; Aldrich, E.F.; Fazl, M.; Fehlings, M.; Herr, D.L.; Hitchon, P.W.; Marshall, L.F.; Nockels, R.P.; Pascale, V.; Perot, P.L.; Piepmeier, J.; Sonntag, V.K.; Wagner, F.; Wilberger, J.E.; Winn, H.R.; Young, W. 1997: Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study JAMA 277(20): 1597-1604
Isu, T. 1990: Spinal cord evoked potential in experimental spinal cord injury--the changes in spinal cord evoked potential following impact injury, and effect of mannitol administration on acute experimental spinal cord injury Hokkaido Journal of Medical Science 65(2): 142-151
Isu, T.; Iwasaki, Y.; Akino, M.; Abe, H. 1990: Effect of mannitol administration and myelotomy on acute experimental spinal cord injury: investigation by spinal cord evoked potential No Shinkei Geka. Neurological Surgery 18(3): 267-272
Zheng, Y.; Zou, X.; Chen, Z.; Zhou, Z.; Shi, Y.; Wang, X.; Cao, P. 2014: Role of new K(+) channel blocker 4-AP-3-MeOH in acute spinal cord compression injury in rats Zhonghua Yi Xue Za Zhi 94(19): 1503-1506
Xu, X.-q.; Xiao, D.; Ju, J.-h. 2003: Animal model of acute spinal cord injury in rats Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 17(1): 22-25
Rao, S.C.; Fehlings, M.G. 1999: The optimal radiologic method for assessing spinal canal compromise and cord compression in patients with cervical spinal cord injury. Part I: An evidence-based analysis of the published literature Spine 24(6): 598-604
Sudo, N. 1980: Clinical application of the evoked spinal cord potentials. Part 1. Neurophysiological assessment of the evoked spinal cord potentials in experimental cord trauma - with reference to cord compression and ischemia Nihon Seikeigeka Gakkai Zasshi 54(12): 1631-1647
Levene, H.B.; Erb, C.J.; Gaughan, J.P.; Loftus, C.M.; Tuma, R.F.; Jallo, J.I. 2007: Hypertonic saline as a treatment for acute spinal cord injury: effects on somatic and autonomic outcomes as observed in a mouse model Clinical Neurosurgery 54: 213-219
Seppälä, M.; Antinheimo, J.; Pohjola, J.; Hernesniemi, J. 2013: Acute spinal cord compression Duodecim; Laaketieteellinen Aikakauskirja 129(24): 2655-2660
Damiani, G.R.; Pellegrino, A.; Gaetani, M.; Loverro, G.; Loverro, M.T. 2015: Acute spinal cord compression in the third trimester of pregnancy Minerva Ginecologica 67(4): 386-387
Fehlings, M.G.; Sekhon, L.H. 2001: Acute interventions in spinal cord injury: what do we know, what should we do? Clinical Neurosurgery 48: 226-242
Beggs, J.L.; Waggener, J.D. 1979: The acute microvascular responses to spinal cord injury Advances in Neurology 22: 179-189
Fishburn, M.J.; Marino, R.J.; Ditunno, J.F. 1990: Atelectasis and pneumonia in acute spinal cord injury Archives of Physical Medicine and Rehabilitation 71(3): 197-200
Sharma, A. 2012: Pharmacological management of acute spinal cord injury Journal of the Association of Physicians of India 60 Suppl: 13-18
Babichenko, E.I.; Belov, V.G.; Ishutin, P.E. 1988: Clinical and roentgenological diagnosis of spinal cord compression in acute closed trauma of the cervical spine Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko 2: 31-35
Günnewicht, B.R. 1995: Pressure sores in patients with acute spinal cord injury Journal of Wound Care 4(10): 452-454
Griffiths, I.R.; Pitts, L.H.; Crawford, R.A.; Trench, J.G. 1978: Spinal cord compression and blood flow. I. The effect of raised cerebrospinal fluid pressure on spinal cord blood flow Neurology 28(11): 1145-1151
Yarkony, G.M.; Formal, C.S.; Cawley, M.F. 1997: Spinal cord injury rehabilitation. 1. Assessment and management during acute care Archives of Physical Medicine and Rehabilitation 78(3 Suppl): S48-S52
Lukáš, R.; Zýková, I.; Barsa, P.; Srám, J. 2011: Current role of methylprednisolone in the treatment of acute spinal cord injury Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca 78(4): 305-313
Young, W. 1993: Strategies for the development of new and better pharmacological treatments for acute spinal cord injury Advances in Neurology 59: 249-256