Lipid transport in hypokinesia and protein deficiency
Sharmanov, T.S.
Ukrainskii Biokhimicheskii Zhurnal 56(3): 293-301
1984
ISSN/ISBN: 0201-8470 PMID: 6464204 Document Number: 226983
Mechanism of lipid transport in blood serum and bile are considered. The main place in interaction of these lipid-transporting systems belongs to endoplasmic reticulum of hepatocytes. The main mechanisms of lipid accretion in the liver with alimentary protein deficiency are established to be a disturbance in the formation of the very low-density lipoproteins and inhibition of cholesterol oxidation into bile acids. The latter is caused by a disturbance in the substrate supply of the given process simultaneously with a decrease in the content of microsomal monooxigenases. It is shown that changes in the motor regime may be the factor determining the diet composition. So, the prolonged hypokinesia necessitates an increase in the portion of animal proteins, which intensifies the processes of cholesterol oxidation in microsomes and lowers the level of atherogenic blood serum lipoproteins.