Pharmacokinetics of tetracycline encapsulated in bovine carrier erythrocytes
DeLoach, J.R.; Wagner, G.G.
American Journal of Veterinary Research 45(4): 640-642
1984
ISSN/ISBN: 0002-9645 PMID: 6731978 Document Number: 226739
Tetracycline was encapsulated in erythrocytes with a dialysis technique. The effect of drug concentration (0.2 mg/ml of erythrocytes) on encapsulation of [14C]sucrose and [3H]tetracycline was reduction of the tetracycline encapsulation, but not [14C]sucrose. Carrier erythrocytes containing tetracycline reinjected in calves were studied for their pharmacokinetic constants. The drug half-life was 6.7 hours, with an overall elimination constant of 0.104 hour-1.