Evidence for a carrier-mediated exchange-diffusion entry of calcium into erythrocytes

Cameron, B.F.; Smariga, P.E.; Cameron, B.F; Smariga, P.E

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Evidence for a carrier-mediated exchange-diffusion entry of calcium into erythrocytes

Cameron, B.F.; Smariga, P.E.

Acta Biologica et Medica Germanica 40(6): 771-777

1981

ISSN/ISBN: 0001-5318

PMID: 7324708

Document Number: 175498

The enthalpy of activation of entry of 45Ca into erythrocytes under conditions of zero net transport (19 Kcal/mol), inhibition of entry by N-ethylmaleimide, and transport pH optimum of 7 - 7.5 are consistent with a protein carrier for inward calcium movement. Initial rate analysis shows saturation kinetics and transstimulation, consistent with a carrier-mediated exchange-diffusion mechanism.