Specific alpha-adrenoceptor-mediated vasoconstriction in human veins and interaction with the calcium entry blockers nifedipine and diltiazem
Schulte, K.L.; Laber, E.; Meyer-Sabellek, W.A.; Distler, A.; Gotzen, R.
Journal of Hypertension. Suppl Official Journal of the International Society of Hypertension 3(3): S239-S241
1985
ISSN/ISBN: 0952-1178 PMID: 2856818 Document Number: 248992
In order to characterize the pharmacological properties of post-junctional alpha-adrenoceptors, the vasoconstricting effects of the non-specific alpha-adrenoceptor agonist noradrenaline, of the specific alpha 1-adrenoceptor agonist phenylephrine and of the specific alpha 2-adrenoceptor agonist azepexole and the interaction with the calcium entry blockers nifedipine and diltiazem were studied in hand veins of eight healthy volunteers. Both subtypes of alpha-adrenoceptors could be demonstrated in human hand veins in vivo. The alpha 1-subtype seemed to prevail. Vasoconstriction induced by stimulation of either post-synaptic alpha 1- or alpha 2-adrenoceptors was reduced by the calcium entry blockers diltiazem and nifedipine.