Staphylococcal lysate fails to elicit nonspecific immune enhancement in a simulated surgical infection
Brown, G.L.; Cobb, J.P.; Brown, C.M.; Polk, H.C.
American Surgeon 50(12): 663-665
1984
ISSN/ISBN: 0003-1348 PMID: 6391313 Document Number: 225279
Staphylococcus aureus produces a delayed-type hypersensitivity reaction, which results in some degree of non-specific immune enhancement. The effects of staphylococcal vaccine (staphage lysate) as a possible potentiator of nonspecific immunity were observed. The experiments were performed in a well-known model simulating surgical infection [Klebsiella pneumoniae in mice]. The experimental results do not support the previously proposed hypothesis that staphylococcal vaccine improves the immune response to a bacterial challenge.