Pharmacological studies of FUT-175, nafamstat mesilate. II. Effects on experimental acute pancreatitis
Iwaki, M.; Ozeki, M.; Sato, T.; Suzuki, K.; Motoyoshi, A.; Suzuki, S.; Fujita, M.; Aoyama, T.
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 84(4): 363-372
1984
ISSN/ISBN: 0015-5691 PMID: 6210233 Document Number: 225042
Effects of FUT-175, a novel synthetic protease-inhibiting agent, on various models of experimental acute pancreatitis were examined. FUT-175 infused i.v. at a dose range of 5-50 .mu.g/kg per min inhibited the increase in plasma trypsin activity and reduced the mortality of rabbits in trypsin-induced acute pancreatitis in a dose-dependent manner. Increase in serum amylase activity and pancreatic tissue lesion were attenuated in rabbits. FUT-175 infused i.v. at a dose range of 1-50 .mu.g/kg per min reduced the mortality of rats in experimental acute pancreatitis produced by trypsin and endotoxin. FUT-175 infused i.v. at a dose range of 1-100 .mu.g/kg per min protected the dogs from the increase in plasma trypsin activity and hypotension and shock induced by trypsin, well-known characteristics of acute pancreatitis. FUT-175 apparently is beneficial as a therapeutic agent of acute pancreatitis.