Catecholamines and their receptors in blood: evidence for alterations in schizophrenia
Bondy, B.; Ackenheil, M.; Birzle, W.; Elbers, R.; Fröhler, M.
Biological Psychiatry 19(10): 1377-1393
1984
ISSN/ISBN: 0006-3223 PMID: 6097309 Document Number: 224948
The simultaneous determination of serum catecholamine (CA) and their receptors in blood cells offers the possibility of evaluating disturbances of the dopamine (DA) and noradrenaline (A) concentrations were nearly unchanged. No overall change in these data was found in the medicated schizophrenic patients. 3H-Spiperone binding was characteristically increased only in schizophrenics, but did not rise above control data in the nonschizophrenic psychiatric control group. Preliminary family studies suggest that this model could be valuable as a vulnerability marker.