Cirrhosis induced by vitamin a
Le Marchand, P.; Benatre, A.; Metman, E.H.; Couët, C.; Arbeille-Brassart, B.; Monegier du Sorbier, C.; Danquechin-Dorval, E.; Grangeponte, M.C.; Bertrand, G.
Gastroenterologie Clinique et Biologique 8(2): 116-120
1984
ISSN/ISBN: 0399-8320 PMID: 6698350 Document Number: 224791
The case of a 75-year-old woman who had been treated for 12 years by vitamin A (250,000 UI/day) for psoriasis is presented. During the hospitalisation, hepatic cirrhosis was detected and attributed to hypervitaminosis A based on disease history, clinical hypervitaminosis A features, increased vitamin A blood values and histological patterns, i. e. perisinusoidal fibrosis and spontaneous fluorescence of lipid vacuoles within fat-storing cells. Thus, although rare, vitamin A intoxication can be responsible for cirrhosis.