Myocardial lesions in experimental acute heart failure
Laky, D.; Constantinescu, S.; Filipescu, G.; Ratea, E.; Hălălău, F.
Morphologie et Embryologie 30(3): 223-227
1984
ISSN/ISBN: 0377-5038 PMID: 6239100 Document Number: 224060
The present study concerns the morphological and biochemical lesional picture of the myocardium in cases of acute heart failure induced by various experimental models: ligature of the coronary artery, direct electric stimulation of the heart by catheterism, lethal hemorrhage, pneumothorax, beta-adrenergic shock. Worthy of note was the similitude of the lesional myocardium pictures characterized electron microscopically by a wide range of lesions, from reversible to focal cytolysis, and biochemically by decrease of mitochondrial enzymes, ATP, Mg2-1 X K+ and increase of Na+ X H2O, Ca2+. Problems linked to the pathogenesis, reversibility of the lesions and efficiency of certain therapeutical means are discussed.