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Molecular genetic analysis of genes encoding the heavy chains of rabbit IgG

Martens, C.L.; Currier, S.J.; Knight, K.L.

Journal of Immunology 133(2): 1022-1027

1984

ISSN/ISBN: 0022-1767
PMID: 6330199
Document Number: 223898
We analyzed the genes which encode the heavy chain constant region of rabbit IgG molecules. Five DNA clones derived from the chromosomal region which spans the C gamma coding sequences were isolated from a recombinant phage library of rabbit liver DNA. Four of these clones can be grouped together by overlaps; together they represent 37 kb of genomic DNA, and contain one C gamma gene and one tentatively identified C epsilon gene. A second C gamma gene was identified which did not overlap with the group of four clones because of restriction site differences found in the flanking regions 5' to the C gamma genes. Nucleotide sequences of the two C gamma genes were identical. Comparisons of the restriction maps of the two cloned C gamma genomic regions suggest that they may represent allelic regions of chromosomes of two different heavy chain haplotypes with polymorphisms in the regions flanking the C gamma genes.

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