Effect of vagotomy on the structure of the gastric mucosa in experimental ulcers
Baĭbekov, I.M.
Arkhiv Anatomii Gistologii i Embriologii 87(9): 58-62
1984
ISSN/ISBN: 0004-1947 PMID: 6508559 Document Number: 223296
Development of experimental gastric ulcers has been investigated in rats from the 2d up to the 120th day using light, electron transmissive, scanning microscopy and radioautography. In 30-60 days after the ulcer induction, there is a clearly seen transmission of the ulcer into a chronic form. In the main and parietal cells at the edge of the ulcer cytoplasm undergoes vacuolization. The edges of the ulcer are formed with glands of the pyloric type. The truncal vagotomy, performed 30 days after the ulcer induction, contributes to epithelization of the ulcer defect. The latter is covered with cells resembling those of the pyloric gland; they are spreading from the edge of the ulcer. The enhanced epithelization of the ulcer after vagotomy is connected with a manifested increase of proliferative activity of the epitheliocytes in the edge of the ulcer. Vagotomy in animals without ulcer also produces an increasing proliferative activity of the cervical cells in corresponding parts of the gastric tunica mucosa.