Long-term changes in the rat gastric mucosa after truncal vagotomy and pyloroplasty
Orrin, T.; Roosaar, P.; Arend, A.; Sepp, E.; Khussar, Y.u.
Morfologiia 114(6): 63-67
1998
ISSN/ISBN: 1026-3543 PMID: 10763492 Document Number: 494702
In 40 male mature albino Wistar rats histological changes of gastric mucosa were analyzed, parietal and chief cells were counted and gastric juice pH was determined 120, 240 and 365 days after truncal vagotomy and pyloroplasty. In all the groups gastric mucosa was attenuated and morphological signs of preatrophic gastritis (decline in parietal cells number, a certain mucoidization of fundal glands without changes in surface epithelium, alteration of mucosal lamina propria) were present. On the background of atrophic changes compensatory and adaptive processes (increase of mitotic activity of epitheliocytes--precursors of differentiating cells, normalization of parietal cells differentiation along the stem line, i.e. of ratio of differentiating, mature functioning and degenerating cell forms) were noted, that lead to repair of histo-structure and function on the whole, although at a lower level. Following long-term intervals after vagotomy glandular gastric epithelium acquires its histo-typical form with parietal secretory activity decreased to some extent.