Clinical, immunologic and electrophysiologic correlations in evaluating multiple sclerosis in relation to its development
Cazzullo, C.L.; Montanini, R.; Ghezzi, A.; Zaffaroni, M.; Giussani, D.; Loner, R.; Caputo, D.; Marforio, S.; Zibetti, A.
Minerva Medica 75(43): 2585-2589
1984
ISSN/ISBN: 0026-4806 PMID: 6392935 Document Number: 222934
49 patients with multiple sclerosis (MS) were evaluated on several lines of investigation: clinical examination with disability rating scale, disease activity staging, multimodal evoked potentials and cerebrospinal fluid analysis. 24 patients were monthly re-examined and T-cell subsets were analysed in the peripheral blood. Evoked potentials were re-evaluated every 3 months in 24 patients. All paramethers were correlated in transversally and longitudinally during a 3 to 18 months follow-up. The results are discussed in the view of a methodological approach to a laboratory evaluation of disease evolution in its natural course and during therapeutic trials.